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April 1, 1974Endocrinology

A Radioimmunoassay for the Direct Measurement of Renin in Mice and Its Application to Submaxillary Gland and Kidney Studies

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Population

Mice (plasma, submaxillary glands, and saliva)

Comparison

Radioimmunoassay using antibodies raised against… vs Bioassay

Design

Preclinical

Authors

AMAndrew M. MichelakisUniversity of North Carolina at Chapel HillHYH. YoshidaSakai Municipal HospitalJMJames W. MenzieVanderbilt University

Discussion

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Implication

Supports murine renin studies; leaves open human translation pending validation.

Structured PICO

P
Population
Mice (plasma, submaxillary glands, and saliva)
I
Intervention
Radioimmunoassay using antibodies raised against purified mouse submaxillary renin
C
Comparator
Bioassay
O
Outcome
Renin concentrationsurrogate

The developed radioimmunoassay provides a direct, rapid, and highly sensitive method for measuring renin in mice, facilitating further physiologic studies.

Cite This Study

Michelakis et al. (1974) studied this question.

synapsesocial.com/papers/6a749f901078cf7de2b1cd7fhttps://doi.org/10.1210/endo-94-4-1101
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immunofluorescent localization of renin in mouse submaxillary gland and kidney.1978 · 15 citations
  2. 2Direct Radioimmunoassay and Immunocytochemical Localization of Renin in Human Kidneys1979 · 12 citations
  3. 3Measurement of Renin Activity, Concentration and Substrate in Rat Plasma by Radioimmunoassay of Angiotensin I1972 · 455 citations
  4. 4Application of a Radioimmunoassay for Angiotensin I to the Measurement of Plasma Renin in Rabbits, and Comparison with a Biological Assay of Plasma Renin Activity1975 · 6 citations
  5. 5Distribution of Exogenously Administered Renin in Mouse Kidney1982 · 6 citations