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December 1, 1979Clinical Science

Direct Radioimmunoassay and Immunocytochemical Localization of Renin in Human Kidneys

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Population

Rabbits (for antibody preparation) and 1 patient with a partially infarcted kidney

Comparison

Direct radioimmunoassay and immunocytochemical… vs Enzymatic method of measurement

Design

Other

Authors

JMJoël MénardPreventive CardiologyPNP. W. N'gocInsermJBJ BariétyInserm

Discussion

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Overview

Supports renin localization to ischaemic renal tissue; leaves open clinical utility of direct radioimmunoassay pending validation.

Structured PICO

P
Population
Rabbits (for antibody preparation) and 1 patient with a partially infarcted kidney
I
Intervention
Direct radioimmunoassay and immunocytochemical localization using fluoresceinated anti-renin antibodies
C
Comparator
Enzymatic method of measurement
O
Outcome
Measurement and localization of renin in plasma and kidney tissuesurrogate

The study demonstrates the feasibility of directly measuring and localizing renin in human plasma and kidney tissue using a specific radioimmunoassay.

Cite This Study

Ménard et al. (1979) studied this question.

synapsesocial.com/papers/6a923ba2467fa0393241da33https://doi.org/10.1042/cs057105s
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Direct radioimmunoassay of human renin: comparison with renin activity in plasma and amniotic fluid.1980 · 41 citations
  2. 2Use of a specific antiserum for renin detection in human kidney.1980 · 65 citations
  3. 3Immunohistochemistry of Renin in Human Diseased Kidney1983 · 6 citations
  4. 4Application of a Radioimmunoassay for Angiotensin I to the Measurement of Plasma Renin in Rabbits, and Comparison with a Biological Assay of Plasma Renin Activity1975 · 6 citations
  5. 5Direct Radioimmunoassays of Renin and Renin Substrate During Converting-Enzyme Inhibition1982 · 9 citations