Why the study?
Does converting enzyme inhibition alter renin and renin substrate levels in severely hypertensive patients?
Population
10 severely hypertensive patients on a low sodium diet
Design
Case_series
Authors
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Converting enzyme inhibition was associated with higher renin and lower substrate in severe hypertension; leaves open clinical relevance pending controlled studies.
Does converting enzyme inhibition alter renin and renin substrate levels in severely hypertensive patients?
Converting enzyme inhibition in severely hypertensive patients increases renin release and decreases renin substrate release, with differences between radioimmunoassay and enzymatic assay reflecting increased substrate consumption.
Genain et al. (1982) studied this question.
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