Immunofluorescence using anti-human renin antibodies reveals distinct patterns of renin localization in normal, ischemic, and nonischemic human kidney tissue.
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Observed patterns in animal kidneys should not alter practice; extends renin mapping but leaves open human translation.
The use of anti-human renin antibodies made possible the intrarenal localization of renin in human kidney by immunofluorescence. In normal kidney, only some juxtaglomerular apparatus (JGA) were fluorescent. In these JGA, granular or diffuse fluorescence was only seen in afferent arterioles and was not present in all cells. In the ischemic areas of partially infarcted kidney, fluorescence was seen in all JGA and in interlobular arteries. In these arteries the most eccentric cells were often the most positive. In the nonischemic areas of the same kidneys, fluorescence was not seen in JGA, but was observed in proximal tubular cells, suggesting the reabsorption of filtered renin at this site.
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Camilleri et al. (1980) studied this question.
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