Population
Kidneys from sodium-deficient rabbits, control rabbits, a sodium-deficient dog, and sodium-deficient rats
Comparison
Canine antisera to rabbit and hog renin coupled… vs Heterogenous antisera and other rabbit tissues
Design
Preclinical
Authors
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Establishes juxtaglomerular cells as renin source in animal kidneys; leaves open human translation and therapeutic targeting.
This study provides strong immunofluorescent evidence that the source of renin in the kidney is the juxtaglomerular cell.
Cady et al. (1961) studied this question.
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