Key result
Aggressive behaviour in male mice without kidneys and salivary glands caused an 800-fold increase in plasma renin concentration from 0.52 to 430 G.U. x 10(-3)/ml.
Population
Male mice without kidneys and submaxillary, as well as sublingual, glands
Comparison
Aggressive behaviour vs Control state (prior to aggression)
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open identification of extra-renal renin sources in stress.
Effect estimate: 800-fold increase
Absolute Event Rate: 430% vs 0.52%
Aggressive behavior in male mice lacking kidneys and submaxillary/sublingual glands triggers a massive release of active renin from an unknown source.
Poulsen et al. (1981) studied this question. Aggressive behaviour vs. Control level was evaluated on Plasma renin concentration (G.U. x 10(-3)/ml) (800-fold increase). Aggressive behaviour in male mice without kidneys and salivary glands caused an 800-fold increase in plasma renin concentration from 0.52 to 430 G.U. x 10(-3)/ml.
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