Key result
Mouse submaxillary renin contains a neutral protease activity that co-purifies with renin and is likely responsible for mediating the activation of human plasma inactive prorenin.
Population
In vitro model using inactive prorenin purified from human plasma and active renin purified from mouse…
Design
Preclinical
Authors
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Animal findings on mouse renin should not inform clinical prorenin management; leaves open whether intrinsic protease activity drives human activation in vivo.
Mouse submaxillary renin possesses intrinsic neutral protease activity capable of converting human plasma inactive prorenin to its active form.
Inagaki et al. (1983) studied this question. Mouse submaxillary renin was evaluated on Protease activity and activation of inactive prorenin. Mouse submaxillary renin contains a neutral protease activity that co-purifies with renin and is likely responsible for mediating the activation of human plasma inactive prorenin.
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