Key result
Aggression spikes plasma renin in male mice but triggers inhibition of the renin-angiotensinogen reaction.
Population
Aggressive male mice with high as well as low concentrations of renin in the submaxillary glands
Comparison
Aggression provocation and intraperitoneally… vs Baseline (before aggression)
Design
Preclinical
Authors
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Animal findings on RAS inhibition during stress do not inform patient care; leaves open human translational relevance.
This preclinical study demonstrates that aggressive male mice have an endogenous mechanism to inhibit and control the renin-angiotensinogen reaction during aggression-provoked renin surges.
Poulsen et al. (1986) studied Aggressive behavior. Aggression vs. Before aggression was evaluated on Plasma renin activity and angiotensinogen concentrations. Aggressive behavior provoked a high increase in plasma renin in male mice, but measured plasma renin activity was much lower than calculated, indicating mice can inhibit the renin-angiotensinogen reaction.
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