Key result
Exogenously administered renin is ultrafiltered through glomerular capillaries and reabsorbed by pinocytosis in the upper third of the proximal convoluted tubule in mice.
This study provides the first demonstration that exogenous renin is ultrafiltered through glomerular capillaries and reabsorbed by pinocytosis in the upper third of the proximal convoluted tubule.
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Informs models of intrarenal renin-angiotensin dynamics in mice; leaves open human relevance or therapeutic implications.
Iwao et al. (1982) studied this question. 125I-labelled purified mouse submaxillary gland renin was evaluated on Distribution of radioactivity in the kidney. Exogenously administered renin is ultrafiltered through glomerular capillaries and reabsorbed by pinocytosis in the upper third of the proximal convoluted tubule in mice.
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