October 24, 2018Frontiers in PharmacologyOpen Access

The Effect of Chinese Medicine on Lipid and Glucose Metabolism in Acute Myocardial Infarction Through PPARγ Pathway

View Full Paper

Ask AI

Bookmark

Why the study?

Does Danqi pill improve cardiac function and energy metabolism in a rat model of heart failure after acute myocardial infarction?

Structured PICO

Does Danqi pill improve cardiac function and energy metabolism in a rat model of heart failure after acute myocardial infarction?

Population

Sprague-Dawley (SD) rats with heart failure after acute myocardial infarction (AMI) induced by left anterior descending artery ligation, and oxygen-glucose deprivation-reperfusion (OGD/R)-induced H9C2 injury cardiomyocyte model

Intervention

Danqi pill (DQP)

Comparator

Model group (untreated HF after AMI) and sham group; in vitro: T0070907 (selective PPARγ inhibitor)

Outcome

Cardiomyocyte morphological changes, cardiac glucose metabolism, adenosine phosphate contents (ATP, energy charge), and expressions of PPARγ, SCP2, and ACADLsurrogate

Danqi pill demonstrates cardioprotective effects and improves energy metabolism in a rat model of post-MI heart failure, potentially mediated through the PPARγ pathway.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for Danqi pill in post-MI HF energy metabolism; leaves open human translation.

Cite This Study

Zhang et al. (2018) studied this question.

synapsesocial.com/papers/6a841e906e9d0d88c0bd89e4 https://doi.org/10.3389/fphar.2018.01209

View Full Paper

Ask AI

Bookmark

The Effect of Chinese Medicine on Lipid and Glucose Metabolism in Acute Myocardial Infarction Through PPARγ Pathway

Structured PICO

Discussion

Implication

Cite This Study

The Effect of Chinese Medicine on Lipid and Glucose Metabolism in Acute Myocardial Infarction Through PPARγ Pathway

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider