Why the study?
Does renal denervation attenuate monocrotaline-induced pulmonary remodeling and improve survival in a rat model of pulmonary artery hypertension?
Population
Male Sprague Dawley rats including 40 with monocrotaline-induced pulmonary remodeling and 8 normal saline…
Comparison
Renal denervation performed either 24 hours or 2… vs Sham RDN operation in MCT-injected rats and sham…
Design
Preclinical
Follow-up
35 days
Authors
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Does not support clinical RDN use in PAH; leaves open timing effects for future translational research.
Does renal denervation attenuate monocrotaline-induced pulmonary remodeling and improve survival in a rat model of pulmonary artery hypertension?
Early renal denervation attenuates cardio-pulmonary fibrosis and improves survival in a rat model of monocrotaline-induced pulmonary hypertension.
Liu et al. (2017) studied this question.
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