April 1, 1977The Journal of PhysiologyOpen Access

An analysis of the action of a false transmitter at the neuromuscular junction.

View Full Paper

Ask AI

Bookmark

Population

Curarized rat muscle and frog muscle preparations

Comparison

Monoethylcholine with electrical stimulation vs Acetylcholine, hemicholinium, triethylcholine…

Design

Preclinical

Authors

DCDavid ColquhounUniversity College London WLW. A. LargeSt George's, University of London HRH P RangBritish Pharmacological Society

Discussion

Member takes

Implication

Does not inform clinical neuromuscular management; leaves open false-transmitter effects on transmission in mammalian models.

Structured PICO

Population

Curarized rat muscle and frog muscle preparations

Intervention

Monoethylcholine (MECh) (0.1-1 mM) with electrical stimulation (e.g., 3 Hz for ~30 min)

Comparator

Acetylcholine (ACh), hemicholinium, triethylcholine, or normal conditions

Outcome

Electrophysiological properties of neuromuscular transmission including end-plate potentials (e.p.p.s.), miniature end-plate potentials (m.e.p.p.s.), miniature end-plate currents (m.e.p.c.s.), and average channel lifetimesurrogate

MECh acts as a false transmitter precursor at the neuromuscular junction, producing AMECh which has lower receptor affinity and shorter channel lifetime than normal acetylcholine.

Cite This Study

Colquhoun et al. (1977) studied this question.

synapsesocial.com/papers/6a84244c002ab1506fb29b7e https://doi.org/10.1113/jphysiol.1977.sp011772

View Full Paper

Ask AI

Bookmark

An analysis of the action of a false transmitter at the neuromuscular junction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

An analysis of the action of a false transmitter at the neuromuscular junction.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider