Preventive Effect of a Fraxinus Excelsior L Seeds/Fruits Extract on Hepatic Steatosis in Obese Type 2 Diabetic Mice

Background: Non-alcoholic fatty liver is recognized as one of harmful consequences of the metabolic syndrome and hepatocytes steatosis is well connected with loss of insulin sensitivity, impaired glucose tolerance and can lead to impaired fasting glucose and type2 diabetes mellitus. Fraxinus excelsior L. seed extract has been used as traditional folk medicine by Mediterranean population and Glucevia, a natural extract of Fraxinus excelsior L. derived from seeds/fruits of the plant and standardized to 10% Nuzhenide and GI3, has been previously reported to regulate glucose homeostasis in healthy overweight people.