Why the study?
Does aspirin or ibuprofen alter the pharmacokinetics and pharmacodynamics of glyburide in healthy subjects?
Population
16 healthy nonsmoking men aged 20-34 years
Comparison
Aspirin 975 mg qid for 4 days or Ibuprofen 600… vs Baseline evaluation with glyburide 5 mg and an…
Design
RCT, randomized, two-way, crossover design
Authors
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Aspirin may raise hypoglycemia risk with glyburide; extends selective NSAID interaction data from this RCT.
Does aspirin or ibuprofen alter the pharmacokinetics and pharmacodynamics of glyburide in healthy subjects?
Aspirin, but not ibuprofen, significantly alters the pharmacokinetics of glyburide, potentially increasing the risk of transient hypoglycemia.
Kubacka et al. (1996) studied this question.