Why the study?
Do different doses of propofol affect post-ECT cognitive recovery, seizure duration, and hemodynamic changes in depressive patients compared to thiamylal?
Do different doses of propofol affect post-ECT cognitive recovery, seizure duration, and hemodynamic changes in depressive patients compared to thiamylal?
In depressive patients undergoing ECT, propofol provides dose-dependent attenuation of hemodynamic responses, but a deep anesthetic level is necessary for early cognitive recovery.
May warrant caution with low-dose propofol in ECT due to cognitive effects; hypothesis-generating and leaves open optimal dosing for hemodynamics.
The effects of different doses of propofol on post-electroconvulsive therapy (ECT) cognitive recovery were evaluated together with the effects on seizure duration and hemodynamic changes during ECT in 15 depressive patients. Propofol attenuated the increase in arterial blood pressure and heart rate in a dose-dependent manner compared with thiamylal. Propofol showed a clinically significant anticonvulsant effect during ECT in a dose-dependent manner. There were no significant differences among the four different induction groups in the mean recovery time from anesthesia, however, a low dose of propofol suppressed the early recovery of cognitive function. For early cognitive recovery after ECT, a deep anesthetic level is necessary when the traditional ECT apparatus is used which produces sine curve wave stimuli.
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Sakamoto et al. (1999) studied this question.
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