Key result
In patients with spinal cord injury, more severe pain symptoms (OR 1.353; 95% CI 1.085-1.793) and poorer leisure time physical activity were independently associated with metabolic syndrome.
Why the study?
Diagnosing metabolic syndrome is challenging in people with spinal cord injury, creating a need to identify clinical risk factors or early markers to facilitate timely diagnosis and preventive or therapeutic strategies.
Cross-Sectional (n=168)
Odds Ratio: 1.353 (95% CI 1.085–1.793)
In patients with spinal cord injury, intense pain symptoms and poor leisure time physical activity are independent predictors of metabolic syndrome.
Pain and inactivity screening may flag metabolic syndrome risk in spinal cord injury; leaves open causal and interventional implications.
Background: The diagnosis of metabolic syndrome (MetS) is a challenge in people with spinal cord injury (SCI). We aimed at identifying clinical risk factors or early markers of MetS in SCI that would facilitate a timely diagnosis and implementation of preventive/therapeutic strategies. Methods: 168 patients with chronic (>1 year) SCI underwent clinical and biochemical evaluations. MetS was diagnosed according to modified criteria of the International Diabetes Federation validated in people with SCI. Results: MetS was diagnosed in 56 of 132 men (42.4%) and 17 of 36 women (47.2%). At univariate regression analyses, putative predictors of MetS were an older age, a higher number of comorbidities, a lower insulin-sensitivity, the presence and intensity of pain, a shorter injury duration, a poorer leisure time physical activity (LTPA) and an incomplete motor injury. At the multiple regression analysis, a significant independent association with MetS only persisted for a poorer LTPA in minutes/week (OR: 0.998, 95%CI: 0.996, 0.999) and more severe pain symptoms as assessed by numeral rating scale (OR: 1.353, 95%CI: 1.085, 1.793). Conclusions: In patients with SCI, intense pain symptoms and poor LTPA may suggest a high likelihood of MetS, regardless of age, SCI duration, motor disability degree, insu-lin-sensitivity and comorbidities.
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Giulio et al. (2023) conducted a cross-sectional in Spinal cord injury (n=168). Severe pain symptoms and poor leisure time physical activity was evaluated on Metabolic syndrome (OR 1.353, 95% CI 1.085-1.793). In patients with spinal cord injury, more severe pain symptoms (OR 1.353; 95% CI 1.085-1.793) and poorer leisure time physical activity were independently associated with metabolic syndrome.
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