Key result
The ED50 of nicardipine required to prevent a hypertensive response to tracheal intubation was significantly lower during induction with propofol (12.5 μg/kg) compared to thiopental or etomidate (both 22.5 μg/kg).
Why the study?
Does the choice of induction agent (propofol, etomidate, or thiopental) affect the ED50 of nicardipine required to prevent a hypertensive response to tracheal intubation?
RCT (n=45)
Sequential allocation (Dixon's up-and-down method)
No
Does the choice of induction agent (propofol, etomidate, or thiopental) affect the ED50 of nicardipine required to prevent a hypertensive response to tracheal intubation?
Induction of anesthesia with propofol requires a significantly lower dose of nicardipine to prevent hypertensive responses during tracheal intubation compared to thiopental or etomidate.
Propofol induction permits lower nicardipine doses to blunt intubation hypertension; extends RCT evidence on induction agent–vasodilator interactions.
, 1) lidocaine, 2) , nitroglycerin sodium nitroprusside , 3) esmolol labetalol 4,5) nicardipine, verapamil, dil-tiazem 6) . , , , 7) lidocaine , 8) . 9) Sodium nitroprusside . 10) , 11) labetalol , esmolol 1 mg/kg , 12) .
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Lim et al. (2004) conducted an RCT in Hypertensive response to tracheal intubation (n=45). Nicardipine vs. Thiopental vs. Propofol vs. Etomidate induction was evaluated on Median effective dose (ED50) of nicardipine for attenuation of hypertensive response after tracheal intubation (95% CI 8.1-16.9, p=<0.05). The ED50 of nicardipine required to prevent a hypertensive response to tracheal intubation was significantly lower during induction with propofol (12.5 μg/kg) compared to thiopental or etomidate (both 22.5 μg/kg).
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