Key result
The ED50 and ED95 of alfentanil to minimize mean arterial pressure increases during laryngoscopy and intubation were 11.2 µg/kg and 24.1 µg/kg, respectively.
Why the study?
Does intravenous alfentanil minimize hemodynamic responses to laryngoscopy and endotracheal intubation in patients undergoing elective surgery?
RCT (n=60)
Divided into four groups
No
Does intravenous alfentanil minimize hemodynamic responses to laryngoscopy and endotracheal intubation in patients undergoing elective surgery?
Intravenous alfentanil effectively minimizes hemodynamic responses to laryngoscopy and endotracheal intubation, with an ED95 of 26.4 μg/kg for mean arterial pressure and 38.6 μg/kg for heart rate.
Informs alfentanil dosing to blunt MAP response to laryngoscopy; extends RCT evidence on opioid attenuation of intubation hemodynamics.
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Park et al. (2004) conducted an RCT in Hemodynamic responses to laryngoscopy and endotracheal intubation (n=60). Alfentanil vs. Normal saline was evaluated on Effective dose (ED50) of alfentanil to prevent >20% increase in mean arterial pressure after intubation (ED50 11.2 µg/kg, 95% CI 4.8-15.6). The ED50 and ED95 of alfentanil to minimize mean arterial pressure increases during laryngoscopy and intubation were 11.2 µg/kg and 24.1 µg/kg, respectively.
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