Key result
Standard statin therapy reducing LDL-C by 20-30% is proposed as an effective strategy for cardiovascular prevention in Japanese patients, as event rates did not differ significantly across achieved LDL-C levels of 50-150 mg/dl.
Why the study?
Does a moderate LDL-C reduction strategy with standard statins prevent cardiovascular events as effectively and safely as aggressive lipid-lowering in Japanese patients?
Does a moderate LDL-C reduction strategy with standard statins prevent cardiovascular events as effectively and safely as aggressive lipid-lowering in Japanese patients?
For Japanese patients who have a lower absolute cardiovascular risk than Western populations, a moderate LDL-C reduction strategy with standard statins may be sufficient and safer than aggressive lipid-lowering.
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May support standard statin therapy in lower-risk Japanese patients; leaves open whether intensive LDL-C lowering adds benefit in RCTs.
Sakamoto et al. (2010) conducted a review in Cardiovascular diseases. Statins vs. Aggressive lipid-lowering therapy was evaluated. Standard statin therapy reducing LDL-C by 20-30% is proposed as an effective strategy for cardiovascular prevention in Japanese patients, as event rates did not differ significantly across achieved LDL-C levels of 50-150 mg/dl.
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