Key result
Sodium hydrosulfide (NaHS) significantly reduced plasma renin activity from 71.9 to 26.1 ng/ml per h and attenuated hypertension in the 2K1C rat model of renovascular hypertension.
Why the study?
Does hydrogen sulfide inhibit plasma renin activity and reduce blood pressure in rat models of renovascular hypertension?
Population
Rat models of renovascular hypertension, normal rats, and primary cultures of renin-rich kidney cells
Comparison
Hydrogen sulfide (H2S) donor NaHS vs Vehicle
Design
Preclinical
Authors
Loading...
Should not yet change clinical practice in renovascular hypertension; hypothesis-generating for hydrogen sulfide modulation of renin in animal models.
Does hydrogen sulfide inhibit plasma renin activity and reduce blood pressure in rat models of renovascular hypertension?
Absolute Event Rate: 26.1% vs 71.9%
p-value: p=<0.01
Hydrogen sulfide inhibits renin activity by decreasing its synthesis and release, suggesting potential therapeutic value for renovascular hypertension.
Lu et al. (2010) studied Renovascular hypertension. Sodium hydrosulfide (NaHS) vs. Vehicle (saline) was evaluated on Plasma renin activity (PRA) in ng/ml per h (p=<0.01). Sodium hydrosulfide (NaHS) significantly reduced plasma renin activity from 71.9 to 26.1 ng/ml per h and attenuated hypertension in the 2K1C rat model of renovascular hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: