July 1, 2001AJP Regulatory Integrative and Comparative Physiology

The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney

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Population

Sprague-Dawley rats

Comparison

Intravenous administration of highly selective… vs Baseline and non-specific NOS inhibitor…

Design

Preclinical

Authors

MKMasao KakokiUniversity of North Carolina at Chapel Hill AZAi-Ping ZouSemmelweis University DMDavid L. MattsonAugusta University

Discussion

Member takes

Implication

NOS1 does not regulate basal renal blood flow in this model despite contributing to interstitial NO; leaves open its role in human renal hemodynamics.

Structured PICO

Population

Sprague-Dawley rats

Intervention

Intravenous administration of highly selective NOS1 inhibitors N(omega)-propyl-L-arginine (L-NPA; 1 mg.kg-1.h-1) or N(5)-(1-imino-3-butenyl)-L-ornithine (v-NIO; 1 mg.kg-1.h-1)

Comparator

Baseline and non-specific NOS inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME)

Outcome

Renal cortical and medullary blood flow and interstitial NO concentrationsurrogate

NOS1 does not regulate basal blood flow in the renal cortex or medulla, despite producing a considerable portion of NO in the renal interstitial space.

Cite This Study

Kakoki et al. (2001) studied this question.

synapsesocial.com/papers/6a842f2be22b852b8ec52a1b https://doi.org/10.1152/ajpregu.2001.281.1.r91

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Implication

NOS1 does not regulate basal renal blood flow in this model despite contributing to interstitial NO; leaves open its role in human renal hemodynamics.

The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider