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October 1, 1969Circulation Research

Structural and Functional Characterization of Dog Heart Microsomes

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Population

Dog heart microsomes and skeletal muscle preparations

Comparison

Various preparation procedures and exposure to… vs Skeletal muscle preparations and different…

Design

Preclinical

Authors

PPPetrus J. PretoriusNorth-West UniversityWPW. Gerhard PohlUniversity of the PacificCSCharles SmithenNational Heart Hospital

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Overview

These features extend preclinical models of cardiac Ca2+ handling; leaves open translation to human disease or therapy.

Structured PICO

P
Population
Dog heart microsomes and skeletal muscle preparations
I
Intervention
Various preparation procedures (including sucrose addition) and exposure to pharmacological agents (caffeine, propranolol, tetracaine, isopropylmethoxamine)
C
Comparator
Skeletal muscle preparations and different preparation methods
O
Outcome
Structural characteristics (via electron microscopy) and functional properties (Ca2+ accumulation, Ca2+ efflux, ATPase activity)surrogate

This preclinical study characterizes the structural and functional properties of dog heart microsomes, highlighting differences in specific activity and calcium handling compared to skeletal muscle.

Cite This Study

Pretorius et al. (1969) studied this question.

synapsesocial.com/papers/6a8431747e95b97f4e72fb28https://doi.org/10.1161/01.res.25.4.487
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preparation of vesicular relaxing factor from bovine heart tissue1964 · 75 citations
  2. 2The Role of Calcium in the Mechanism of Relaxation of Cardiac Muscle1964 · 138 citations
  3. 3Quantitative Aspects of Dog Cardiac Microsomal Calcium Binding and Calcium Uptake1967 · 110 citations
  4. 4Activity of the Vesicular Calcium Pump in the Spontaneously Failing Heart-Lung Preparation1967 · 82 citations
  5. 5Calcium Uptake Activity of Canine Myocardial Sarcoplasmic Reticulum in the Presence of Anesthetic Agents1968 · 59 citations