Population
Isolated rat heart model
Comparison
Perfusion with medium containing Ca45 and in… vs Sarcoplasmic reticulum vs mitochondria; presence…
Design
Preclinical
Authors
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Hypothesis-generating for mitochondrial calcium handling in cardiac tissue; leaves open translation to human physiology or therapy.
This preclinical study suggests that free calcium concentration in the heart is determined mainly by the activities of mitochondria, sarcoplasmic reticulum, contractile proteins, and cell membrane movements.
Dhalla et al. (2008) studied this question.
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