Key result
In mouse models, the Angpt2443 isoform impaired venous development, differentially affected primary tumor growth, and promoted destabilization of pulmonary vasculature and lung metastasis.
Why the study?
Blocking ANGPT2 is a promising strategy to inhibit tumor growth and metastasis, but variable effects have complicated drug development.
Does the expression of the Angpt2443 isoform affect vascular remodeling, tumor growth, and metastasis in mouse models?
Population
Knock-in mice expressing Angpt2443, MMTV-PyMT, B16F10 melanoma, and E0771 breast cancer models
Comparison
Expression of Angpt2443 vs controls or baseline
Design
Preclinical animal and in vitro study
Authors
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Preclinical Angpt2443 effects do not inform patient care; leaves open human validation of its role in metastasis.
Does the expression of the Angpt2443 isoform affect vascular remodeling, tumor growth, and metastasis in mouse models?
The N-terminal oligomerization domain of angiopoietin-2 plays a critical role in vascular remodeling, tumor growth, and lung metastasis, highlighting mechanisms underlying its versatile functions in cancer.
Kapiainen et al. (2020) studied Cancer (breast cancer, melanoma) and angiogenesis. Angpt2443 (lower oligomeric protein isoform of ANGPT2) was evaluated on Vascular remodeling, mammary gland tumor growth, and lung metastasis. In mouse models, the Angpt2443 isoform impaired venous development, differentially affected primary tumor growth, and promoted destabilization of pulmonary vasculature and lung metastasis.
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