Key result
The Ang-Tie signalling system is a key endothelial cell-specific pathway regulating cardiovascular and lymphatic development, vascular homoeostasis, and the pathogenesis of numerous vascular diseases.
Design
Review
Authors
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May guide Ang-Tie-targeted therapies in vascular disease; leaves open clinical validation in prospective trials.
This review highlights the critical role of the Ang-Tie signalling pathway in vascular homeostasis and its implication in various vascular and systemic diseases.
Eklund et al. (2016) conducted a review in Vascular diseases. Angiopoietin-Tie signalling system was evaluated. The Ang-Tie signalling system is a key endothelial cell-specific pathway regulating cardiovascular and lymphatic development, vascular homoeostasis, and the pathogenesis of numerous vascular diseases.
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