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February 9, 2021EyeOpen Access

Preclinical evidence suggests that modulating the Ang/Tie pathway restores vascular stabilisation and reduces inflammation.

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Why the study?

The Ang/Tie pathway is an emerging regulator of vascular stability and inflammation, highlighting its relevance as a potential therapeutic target in retinal and choroidal vascular diseases.

Does targeting the Ang/Tie pathway or applying Ang-2/VEGF-A combination therapy restore vascular stability and reduce inflammation in retinal and choroidal vascular diseases?

Design

Review

Authors

AJAntonia M. JoussenFRFederico RicciLPLiliana P Paris

Discussion

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Overview

Should not change practice in retinal diseases; leaves open translation of Ang/Tie modulation to clinical trials.

Structured PICO

Does targeting the Ang/Tie pathway or applying Ang-2/VEGF-A combination therapy restore vascular stability and reduce inflammation in retinal and choroidal vascular diseases?

P
Population
Preclinical models of retinal and choroidal vascular diseases
I
Intervention
Modulating the Ang/Tie pathway or applying Ang-2/VEGF-A combination therapy
O
Outcome
Vascular stability and inflammation

Targeting the Ang/Tie pathway or using Ang-2/VEGF-A combination therapy may be a valuable therapeutic strategy for restoring vascular stability and reducing inflammation in retinal and choroidal vascular diseases.

Cite This Study

Joussen et al. (2021) studied this question.

synapsesocial.com/papers/69dbb1d5c9a120f055a3c482https://doi.org/10.1038/s41433-020-01377-x
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