Population
Human umbilical vein endothelial cell cDNA, COS-7 cells, primary endothelial cells, nonendothelial tumor…
Comparison
Recombinant Ang2 expression and characterization vs Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2)
Design
Preclinical
Authors
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May act as endogenous Tie2 antagonist; hypothesis-generating for angiogenesis regulation, pending human validation.
The discovery of Ang2(443), a novel alternatively spliced variant of Angiopoietin-2, reveals a functional antagonist of Ang1 that may play a key role in regulating angiogenesis.
Kim et al. (2000) studied this question.
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