Key result
ANGPT2443 and its cleaved isoform ANGPT2DAP acted as potent inhibitors of ANGPT1-TIE2 signaling, impairing vessel enlargement and vein morphogenesis compared with full-length ANGPT2.
Population
cellular models and Angpt2443-expressing mice
Comparison
ANGPT2443 and ANGPT2DAP vs full-length ANGPT2
Design
Editorial
Authors
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The alternatively spliced ANGPT2443 and its cleaved form ANGPT2DAP act as a biological rheostat of ANGPT1-TIE2 signaling, providing new insights into vascular biology and tumor metastasis.
The alternatively spliced ANGPT2443 and its cleaved form ANGPT2DAP act as a biological rheostat of ANGPT1-TIE2 signaling, providing new insights into vascular biology and tumor metastasis.
Kamiyama et al. (2021) reported an editorial. ANGPT2443 vs. Full-length ANGPT2 was evaluated. ANGPT2443 and its cleaved isoform ANGPT2DAP acted as potent inhibitors of ANGPT1-TIE2 signaling, impairing vessel enlargement and vein morphogenesis compared with full-length ANGPT2.
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