Key Points
- To evaluate the expression of angiopoietin 1 and 2 in benign and malignant prostate tissues and assess their relationship with vascular density and clinical outcomes.
- Immunolocalized angiopoietin 1 and 2 in transurethral resection (TUR)-diagnosed prostate tumor specimens from patients with long-term follow-up.
- Analyzed associations between angiopoietin expression levels, endoglin-positive blood vessel density, Gleason score, metastatic status, and cancer-specific survival.
- Angiopoietin 1 showed strong expression in basal epithelial cells of non-malignant tissue but lower levels in tumor epithelial cells.
- Angiopoietin 2 exhibited weak staining in non-malignant tissue and low-to-intermediate Gleason score tumors, but intense staining in high Gleason score tumors.
- Elevated angiopoietin 2 expression significantly correlated with higher Gleason score, increased endoglin-positive vascular density, presence of metastases, and poorer cancer-specific survival.
Structured PICO
PPopulationPatients with TUR-diagnosed prostate tumors
OOutcomeCorrelation of Angiopoietin 1 and 2 expression with vascular density, clinicopathological variables, metastases, and cancer-specific survivalsurrogate
Angiopoietin 2 expression is significantly correlated with higher Gleason score, angiogenesis, metastases, and cancer-specific survival in prostate cancer, suggesting it is an important regulator of angiogenesis in this malignancy.