Why the study?
Angiopoietin-2 is thought to play an essential role in oral squamous cell carcinoma development and progression, but its correlation with clinicopathological parameters needed assessment.
Angiopoietin-2 expression is significantly associated with the histopathological grade of oral squamous cell carcinoma, suggesting it may predict tumor biological behavior.
Ang-2 may mark OSCC aggressiveness; hypothesis-generating and requires prospective validation before clinical use.
Background: There are various secreted proteins affecting the prognosis of oral squamous cell carcinoma (OSCC) and one of them is Angiopoietin-2(Ang-2) which is thought to have an essential role in the development and progression of the tumor. Aim of the study: This study was conducted to determine the expression of (Ang-2) in (OSCC) to assess its correlations with clinicopathological parameters of the tumor. Material and Methods: 36 formalin- fixed, paraffin- embedded tissue blocks histologically diagnosed as OSCC were examined for Ang-2 immunohistochemical expression semi quantitively. Results: The expression of Ang-2 was significantly associated with histopathological grade (P value=0.023), while there is no significant association with the clinical parameters analyzed in OSCC patients. Conclusion: A significant association between Ang-2 expression and histopathological grade of OSCC may predict its biological behavior.
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Sarraf et al. (2019) studied this question.
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