Key result
High Ang-1 and Ang-2 expression indicated aggressive tumor behavior, but only recurrent tumor stage was an independent prognostic factor for survival (RR 10.992; 95% CI 1.473-82.017; P=0.019).
Why the study?
Does Ang-1 and Ang-2 expression predict survival outcomes in patients with recurrent squamous cell carcinoma of the oral cavity?
Observational (n=40)
Does Ang-1 and Ang-2 expression predict survival outcomes in patients with recurrent squamous cell carcinoma of the oral cavity?
Relative Risk: 10.992 (95% CI 1.473–82.017)
p-value: p=0.019
In recurrent squamous cell carcinoma of the oral cavity, high Ang-1 or Ang-2 expression indicates aggressive tumor behavior, though salvage outcome primarily depends on the recurrent tumor stage.
Recurrent stage should guide salvage decisions in oral cavity SCC; leaves open Ang-1/2 as independent biomarkers pending prospective validation.
BACKGROUND AND OBJECTIVES: Our objective was to evaluate the clinical significance of angiopoietin-1 (Ang-1) and Ang-2 expression in recurrent but operable squamous cell carcinoma of the oral cavity (OCSCC). PATIENTS AND METHODS: Formalin-fixed, paraffin-embedded tissues from 40 patients who underwent surgical intervention for local or local-regional recurrent OCSCC between 1995 and 2005 were immunohistochemically analyzed for Ang-1 and Ang-2 expression. RESULTS: The recurrent TNM staging classified 5 patients as stage I, 4 as stage II, 2 as stage III, and 29 as stage IV. The actuarial 3-year disease-free survival rate was 43.1% with a mean follow-up of 18.4 months (ranged 1-70 months). High expression of Ang-1 was significantly correlated with positive nodal stage (P = 0.041). Patients with more advanced recurrent stage of the tumors (P = 0.0036) and high expression of Ang-2 (P = 0.045) showed lower actuarial 3-year disease-free survival. However, Cox's regression analysis revealed that only recurrent tumor (rT) stage was an independent prognostic factor for survival (P = 0.019, 95% CI = 1.473-82.017, relative risk = 10.992). CONCLUSIONS: Recurrent OCSCC with high Ang-1 or Ang-2 expression in the tumor bed exhibits aggressive tumor behavior. However, the salvage outcome depends on the rT stage.
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Chien et al. (2007) conducted an observational in Recurrent but operable squamous cell carcinoma of the oral cavity (OCSCC) (n=40). Angiopoietin-1 and -2 expression and recurrent tumor stage vs. Low expression / lower stage was evaluated on Survival (RR 10.992, 95% CI 1.473-82.017, p=0.019). High Ang-1 and Ang-2 expression indicated aggressive tumor behavior, but only recurrent tumor stage was an independent prognostic factor for survival (RR 10.992; 95% CI 1.473-82.017; P=0.019).
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