Key result
Higher expression of Ang-2 and cyclin D1 in laryngeal squamous cell carcinoma correlated significantly with poorer tumor differentiation, lymph node metastasis, and reduced overall survival.
Observational (n=116)
No
Ang-2 and cyclin D1 expression are correlated with tumor differentiation and survival in laryngeal squamous cell carcinoma, suggesting potential as prognostic biomarkers.
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May inform prognostic stratification in laryngeal squamous cell carcinoma; hypothesis-generating and requires prospective validation.
The aim of this study was to study the expression of angiopoietin-2 (Ang-2) and the cell cycle protein D1 (cyclin D1) in laryngeal squamous cell carcinoma (SCC), and its clinicopathological meaning. The expression of Ang-2 and cyclin D1 was analyzed in 116 cases of laryngeal SCC, five cases of atypical hyperplasia and five cases of vocal polyp tissues using the immunohistochemical streptavidin-perosidase (S-P) method. Ang-2 and cyclin D1 protein expression was not present in 5 cases of atypical hyperplasia or 5 cases of vocal cord polyps. However, the proportions of positive staining in well, moderately and poorly differentiated laryngeal SCC were 40, 66.7 and 100%, respectively, for Ang-2 and 50, 66.7, 100%, respectively, for cyclin D1, and were statistically significant (P<0.05). The expression of Ang-2 was positively correlated with cyclin D1 in the laryngeal SCC (r=0.5042; P<0.05). This showed that the tumor grading and cyclin D1 were independent factors affecting laryngeal SCC patient survival by the Cox regression model of risk factors proportion analysis. Ang-2 is synergistic with cyclin D1 in the development of laryngeal SCC. Ang-2 is associated with the metastasis of lymph nodes. Detection of both Ang-2 and cyclin D1 may possess clinical significance in evaluating the prognosis and guiding the clinical treatment of SCC.
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Liu et al. (2013) conducted an observational in Laryngeal squamous cell carcinoma (n=116). Angiopoietin-2 (Ang-2) and cyclin D1 expression vs. Negative expression / benign tissues was evaluated on Overall survival and clinicopathological correlation (p=<0.05). Higher expression of Ang-2 and cyclin D1 in laryngeal squamous cell carcinoma correlated significantly with poorer tumor differentiation, lymph node metastasis, and reduced overall survival.
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