Key result
Cardiac contractility modulation using the OPTIMIZER System was technically feasible and coexisted without interference with a CRT-D device, yielding acute haemodynamic and clinical improvements.
Why the study?
Does cardiac contractility modulation (CCM) improve acute haemodynamic and clinical outcomes in a patient failing CRT therapy?
Case Report (n=1)
Does cardiac contractility modulation (CCM) improve acute haemodynamic and clinical outcomes in a patient failing CRT therapy?
Answers are grounded in this paper and cite their sources.
CCM may be a technically feasible and potentially beneficial therapeutic option for heart failure patients who are non-responders to CRT therapy.
Cardiac contractility modulating (CCM) signals delivered by the OPTIMIZER System are being investigated as a treatment for medically refractory heart failure. Previous chronic studies of CCM have excluded patients with prolonged QRS and a cardiac resynchronization therapy (CRT) device. However, symptoms persist in more than 25% of these CRT patients. CCM may offer a therapeutic option for these non-responders. Here we report the first use of CCM signals in a patient who did not respond to treatment with a CRT-D device. We show that the implantation is technically feasible, that the OPTIMIZER and CRT-D devices can coexist without interference and that acute haemodynamic and clinical improvements can be observed. The results suggest that systematic investigation of CCM treatment in CRT non-responders is warranted.
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Butter et al. (2007) conducted a case report in Medically refractory heart failure failing CRT therapy (n=1). Cardiac contractility modulation (CCM) via the OPTIMIZER System was evaluated on Technical feasibility, device coexistence without interference, and acute haemodynamic and clinical improvements. Cardiac contractility modulation using the OPTIMIZER System was technically feasible and coexisted without interference with a CRT-D device, yielding acute haemodynamic and clinical improvements.
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