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November 2, 2023Texas Heart Institute JournalOpen Access

Established and Emerging Device Therapy in Heart Failure: Cardiac Contractility Modulation

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Key result

CCM improves exercise tolerance, quality of life, and reduces HF hospitalizations in selected HFrEF patients.

Why the study?

Cardiac resynchronization therapy is detrimental in patients with HFrEF and QRS duration less than 120 ms, creating a need for effective device therapies in this underserved population.

Does cardiac contractility modulation improve symptoms and clinical outcomes in patients with HFrEF and QRS duration less than 120 ms?

Design

Review

Authors

JHJustin HalootMCMihail G. Chelu

Discussion

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Overview

May support CCM for narrow-QRS HFrEF ineligible for CRT; leaves open confirmation in larger randomized trials.

Structured PICO

Does cardiac contractility modulation improve symptoms and clinical outcomes in patients with HFrEF and QRS duration less than 120 ms?

P
Population
Patients with heart failure with reduced ejection fraction (HFrEF), specifically those with LVEF 25% to 45%, normal sinus rhythm or atrial fibrillation with QRS duration less than 120 ms, and NYHA class III or ambulatory class IV disease.
I
Intervention
Cardiac contractility modulation (CCM) via an implantable pulse generator delivering high-voltage (approximately 7.5 V), long-duration (approximately 20 ms) electrical signals during the absolute refractory period.

Cardiac contractility modulation provides a beneficial device-based therapeutic option for patients with HFrEF and narrow QRS who are ineligible for cardiac resynchronization therapy.

Cite This Study

Haloot et al. (2023) conducted a review in Heart failure with reduced ejection fraction (HFrEF). Cardiac contractility modulation (CCM) was evaluated. Cardiac contractility modulation is a beneficial device-based therapy for selected patients with HFrEF, improving exercise tolerance, quality of life, and reducing heart failure hospitalizations.

synapsesocial.com/papers/6a20195e40c8e71b0ba1a7e6https://doi.org/10.14503/thij-23-8184
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac contractility modulation by electric currents applied during the refractory period2002 · 85 citations
  2. 2Cardiac-Resynchronization Therapy in Heart Failure with Narrow QRS Complexes2007 · 797 citations
  3. 3A Randomized Controlled Trial to Evaluate the Safety and Efficacy of Cardiac Contractility Modulation2018 · 272 citations
  4. 4Randomized, double blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure2008 · 239 citations
  5. 5Cardiac Contractility Modulation by Non-Excitatory Currents: Studies in Isolated Cardiac Muscle2005 · 98 citations