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January 1, 2016Rational Pharmacotherapy in CardiologyOpen Access

Modulation of Cardiac Contractility – a New Method in the Treatment of Heart Failure

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Key result

Cardiac contractility modulation therapy had a beneficial effect on survival and quality of life in patients with chronic heart failure and normal QRS duration.

Why the study?

Does cardiac contractility modulation improve outcomes in patients with chronic heart failure with low ejection fraction and normal QRS duration?

Population

617 patients with chronic heart failure with low ejection fraction, normal QRS duration, and NYHA class II…

Design

Review

Authors

АПА. А. ПетрухинаСТС. Н. ТерещенкоИЖИ. В. Жиров

Discussion

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Overview

May support CCM consideration in non-CRT HF patients; leaves open need for randomized confirmation.

Structured PICO

Does cardiac contractility modulation improve outcomes in patients with chronic heart failure with low ejection fraction and normal QRS duration?

P
Population
617 patients with chronic heart failure, low ejection fraction, normal QRS duration, and NYHA class II-III on optimal medical therapy across three randomized trials.
I
Intervention
Cardiac contractility modulation (CCM) added to maximum active therapy

Cardiac contractility modulation appears to improve survival and quality of life in heart failure patients with low ejection fraction and normal QRS duration who are not candidates for cardiac resynchronization therapy.

Limitations

  • More data is needed to assess long-term effects of the CCM therapy.
  • more data is needed to assess long-term effects of the CCM therapy

Cite This Study

Петрухина et al. (2016) conducted a review in Chronic heart failure with low ejection fraction (n=617). Cardiac contractility modulation (CCM) vs. Optimal medical therapy was evaluated on Survival and quality of life. Cardiac contractility modulation therapy had a beneficial effect on survival and quality of life in patients with chronic heart failure and normal QRS duration.

synapsesocial.com/papers/6a92fd4ece62e2ff0971f703https://doi.org/10.20996/1819-6446-2016-12-5-574-581
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac Contractility Modulation in 20182018 · 46 citations
  2. 2Cardiac contractility modulation: a novel approach for the treatment of heart failure2016 · 82 citations
  3. 3Clinical Effects of Cardiac Contractility Modulation (CCM) as a Treatment for Chronic Heart Failure2012 · 71 citations
  4. 4Cardiac contractility modulation in patients with advanced heart failure2013 · 13 citations
  5. 5Cardiac contractility modulation in heart failure management: unraveling molecular mechanisms to improve patient selection in heart failure management2026