Key result
Acetylcholine-induced vasodilation in rat sciatic nerve consists of two components, partially mediated by EDHF and by a vasodilatory prostanoid plus NO.
Population
Rat sciatic nerve model
Comparison
Acetylcholine and 3-morpholinosydnonimine with… vs Baseline or absence of specific inhibitors
Design
Preclinical
Authors
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Rat sciatic nerve findings remain preclinical; leaves open EDHF/NO-prostanoid contributions to human peripheral nerve vasoregulation.
In the rat sciatic nerve, acetylcholine-induced vasodilation is biphasic, involving both EDHF and NO/prostanoid pathways, while baseline microvascular conductance depends on NO and EDHF.
Rubin et al. (2000) studied this question. Acetylcholine and 3-morpholinosydnonimine was evaluated on Vasodilation and baseline blood flow (nerve microvascular conductance). Acetylcholine-induced vasodilation in rat sciatic nerve consists of two components, partially mediated by EDHF and by a vasodilatory prostanoid plus NO.
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