January 1, 1982The Journal of Biochemistry

Electron Microscopic Studies of Myosin Molecules from Chicken Gizzard Muscle I: The Formation of the Intramolecular Loop in the Myosin Tail1

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Population

Chicken gizzard myosin molecules from "thick filaments"

Comparison

Disassembly by ATP vs Disassembly by high concentrations of ammonium…

Design

Preclinical

Authors

HOHirofumi OnishiTokyo Medical and Dental University TWTakeyuki WakabayashiThe University of Tokyo

Discussion

Member takes

Implication

Warrants caution against extrapolating avian smooth-muscle findings to cardiac myosin; leaves open in-vivo relevance for contractility.

Structured PICO

Population

Chicken gizzard myosin molecules from "thick filaments"

Intervention

Disassembly by ATP

Comparator

Disassembly by high concentrations of ammonium acetate without ATP

Outcome

Structural differences observed via electron microscopy (rotary-shadowing technique)surrogate

This basic science study demonstrates that ATP induces specific structural changes in chicken gizzard myosin molecules, including the formation of an intramolecular hairpin loop in the tail.

Cite This Study

Onishi et al. (1982) studied this question.

synapsesocial.com/papers/6a843db0309bd08d91730bae https://doi.org/10.1093/oxfordjournals.jbchem.a134001

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Electron Microscopic Studies of Myosin Molecules from Chicken Gizzard Muscle I: The Formation of the Intramolecular Loop in the Myosin Tail1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electron Microscopic Studies of Myosin Molecules from Chicken Gizzard Muscle I: The Formation of the Intramolecular Loop in the Myosin Tail1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider