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January 1, 1987British Journal of PharmacologyOpen Access

3H‐verapamil binding to rat cardiac sarcolemmal membrane fragments; an effect of ischaemia

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Population

Adult male Sprague-Dawley rats (250-300 g), normotensive

Comparison

60 min global ischemia at 37°C vs 60 min aerobic perfusion at 37°C

Design

Preclinical, hearts were randomly divided into two groups

Authors

JDJ. S. DillonThe University of MelbourneWNW. G. NaylerCross-Cutting Cardiology

Discussion

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Implication

Ischemia alters verapamil binding in rat myocardium; hypothesis-generating for effects on calcium antagonists in human ischemia.

Structured PICO

P
Population
Adult male Sprague-Dawley rats (250-300 g), normotensive
I
Intervention
60 min global ischemia at 37°C (totally occluding coronary flow in Langendorff perfused hearts)
C
Comparator
60 min aerobic perfusion at 37°C
O
Outcome
[3H]-verapamil binding activity (KD and Bmax) of cardiac sarcolemmal fragmentssurrogate

Normothermic ischemia significantly reduces the density and dissociation constant of verapamil binding sites in rat cardiac sarcolemma, while maintaining binding selectivity.

Cite This Study

Dillon et al. (1987) studied this question.

synapsesocial.com/papers/6a843ed36e9d0d88c0bd9752https://doi.org/10.1111/j.1476-5381.1987.tb16829.x
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sarcolemmal enzymes and Na+ -Ca2+ exchange in hypoxic, ischemic, and reperfused rat hearts1984 · 47 citations
  2. 2The Use of Ligand Binding for the Characterisation of α-Adrenoceptors1980 · 31 citations