Why the study?
Does propranolol improve right ventricular outflow obstruction and symptoms in a patient with hypertrophic cardiomyopathy?
Does propranolol improve right ventricular outflow obstruction and symptoms in a patient with hypertrophic cardiomyopathy?
Propranolol effectively abolished the inspiratory right ventricular outflow tract pressure gradient and controlled symptoms in a patient with familial hypertrophic cardiomyopathy.
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Propranolol may relieve RVOT obstruction in HCM; single case leaves open efficacy and safety in broader populations.
A patient with familial hypertrophic cardiomyopathy with exertional near syncope is reported. Intra-right ventricular obstruction was demonstrated by hemodynamic studies during inspiration and the Valsalva maneuver with systemic hypotension. Improvement occurred following the administration of propranolol. It was suggested that syncope might be precipitated by hemodynamic changes such as a high output state and a depressed cardiac volume in relation to intra-right ventricular obstruction in patients with hypertrophic cardiomyopathy.
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Tsuchihashi et al. (1988) studied this question.
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