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Supports mechanistic rationale for vasodilator selection in hypertension; leaves open prospective outcome trials for system-targeted personalization.
Total peripheral resistance and regional blood flow are determined by the contractile activity of vascular smooth muscle cells. The control systems that determine the activity of arterial smooth muscle are described. The interactions among control systems that underlie the remarkable diversity in the responses of blood vessels are emphasized to illustrate how various classes of drugs mediate clinically important effects.
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Richard A. Murphy (1983) studied this question.
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