November 1, 1995AJP Cell Physiology

Thiophosphorylation independently activates each head of smooth muscle myosin in vitro

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Population

Chicken gizzard smooth muscle myosin

Comparison

Random thiophosphorylation vs Mixtures of unphosphorylated and doubly…

Design

Preclinical

Authors

DHDavid HarrisUniversity of Vermont CSChristopher J. StromskiFundación Juan March EHEnda HayesUniversity of the West of England

Discussion

Member takes

Implication

Hypothesis-generating for smooth muscle regulation; extends biochemical models of single-head activity but leaves open in vivo relevance.

Structured PICO

Population

Chicken gizzard smooth muscle myosin

Intervention

Random thiophosphorylation (producing a mixture of unphosphorylated, singly, and doubly thiophosphorylated myosin)

Comparator

Mixtures of unphosphorylated and doubly thiophosphorylated myosin

Outcome

Biochemical and mechanical activity measured by actin-activated adenosinetriphosphatase and in vitro motility assaysurrogate

A single thiophosphorylated smooth muscle myosin head can produce substantial biochemical and mechanical activity independently of its unphosphorylated partner.

Cite This Study

Harris et al. (1995) studied this question.

synapsesocial.com/papers/6a843ffa4d02f4f0268d769b https://doi.org/10.1152/ajpcell.1995.269.5.c1160

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Thiophosphorylation independently activates each head of smooth muscle myosin in vitro

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Thiophosphorylation independently activates each head of smooth muscle myosin in vitro

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider