Light chain phosphorylation regulates the movement of smooth muscle myosin on actin filaments.
Population
In vitro assay using turkey gizzard smooth muscle myosin and ordered actin filaments derived from the giant…
Comparison
Phosphorylation of the 20-kD myosin light chains vs Unphosphorylated myosin
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Warrants validation in intact smooth muscle; leaves open translation to cardiovascular contractility or therapy.
Structured PICO
P
Population
In vitro assay using turkey gizzard smooth muscle myosin and ordered actin filaments derived from the giant alga, Nitella
I
Intervention
Phosphorylation of the 20-kD myosin light chains
C
Comparator
Unphosphorylated myosin
O
Outcome
Rate of movement of myosin-coated beads on actin filaments
Phosphorylation of both heads of a myosin molecule is required for the movement of smooth muscle myosin on actin filaments.
Cite This Study
Sellers et al. (1985) studied this question.