December 1, 1986AJP Cell Physiology

Slowing of cross-bridge cycling in smooth muscle without evidence of an internal load

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Population

Rabbit taenia coli (mammalian smooth muscle)

Comparison

Stimulation for 25 s under isometric conditions… vs Initial stimulation

Design

Preclinical

Authors

TBT. M. ButlerUniversity of Calgary MSMarion J. SiegmanCincinnati Eye Institute SMSusan U. MooersThomas Jefferson University

Discussion

Member takes

Implication

Supports cross-bridge slowing over latch bridges for energy-efficient smooth muscle force; leaves open translation to human vascular regulation.

Structured PICO

Population

Rabbit taenia coli (mammalian smooth muscle)

Intervention

Stimulation for 25 s under isometric conditions followed by 30 s of relaxation prior to the test stimulus

Comparator

Initial stimulation

Outcome

Maximum velocity of shortening and chemical energy usagesurrogate

Force maintenance with low energy input and slow shortening velocity in mammalian smooth muscle is due to a general slowing of cross-bridge cycling rate rather than an internal load from latch bridges.

Cite This Study

Butler et al. (1986) studied this question.

synapsesocial.com/papers/6a843ffa4d02f4f0268d76a2 https://doi.org/10.1152/ajpcell.1986.251.6.c945

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Implication

Supports cross-bridge slowing over latch bridges for energy-efficient smooth muscle force; leaves open translation to human vascular regulation.

Slowing of cross-bridge cycling in smooth muscle without evidence of an internal load

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Slowing of cross-bridge cycling in smooth muscle without evidence of an internal load

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider