June 1, 1988The Journal of General PhysiologyOpen Access

Characterization of cross-bridge elasticity and kinetics of cross-bridge cycling during force development in single smooth muscle cells.

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Population

Single smooth muscle cells isolated from the toad (Bufo marinus) stomach muscularis

Design

Preclinical

Authors

DWDavid M. WarshawUniversity of Vermont DRDaffyd ReesUniversity of Massachusetts Chan Medical School FFF S FayUniversity of Vermont

Discussion

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Implication

May refine smooth muscle contraction models; leaves open relevance to human vascular function.

Structured PICO

Population

Single smooth muscle cells isolated from the toad (Bufo marinus) stomach muscularis

Intervention

Small sinusoidal length changes (0.5% cell length, 250 Hz) and small, rapid step length changes (0.5% cell length in 2.5 ms)

Outcome

Active muscle stiffness and time course of tension recoverysurrogate

The kinetics of force production in smooth muscle may involve a redistribution of cross-bridge populations between two attached states, with the average cycling rate slowing over time during contraction.

Cite This Study

Warshaw et al. (1988) studied this question.

synapsesocial.com/papers/6a73643bc8f0e053d4566346 https://doi.org/10.1085/jgp.91.6.761

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Characterization of cross-bridge elasticity and kinetics of cross-bridge cycling during force development in single smooth muscle cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of cross-bridge elasticity and kinetics of cross-bridge cycling during force development in single smooth muscle cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider