April 1, 1990The Journal of General PhysiologyOpen Access

Mechanical transients of single toad stomach smooth muscle cells. Effects of lowering temperature and extracellular calcium.

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Population

Single smooth muscle cells from the toad stomach (Bufo marinus)

Comparison

Lowering cell temperature and lowering… vs Room temperature and normal extracellular calcium

Design

Preclinical

Authors

MYM YamakawaUniversity of Vermont DHDavid HarrisUniversity of Vermont FFF S FayUniversity of Vermont

Discussion

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Implication

Hypothesis-generating for smooth muscle crossbridge kinetics; leaves open translation to mammalian cardiovascular physiology.

Structured PICO

Population

Single smooth muscle cells from the toad stomach (Bufo marinus)

Intervention

Lowering cell temperature (10 degrees C) and lowering extracellular calcium (0.18 mM)

Comparator

Room temperature (20 degrees C) and normal extracellular calcium (1.8 mM)

Outcome

Tension recovery time course (tension transients) in response to a small, rapid length changesurrogate

In toad stomach smooth muscle cells, lowering temperature slows the fast tension recovery phase, while lowering extracellular calcium has little effect on tension transients, suggesting crossbridges cycle slower and have a longer duty cycle in smooth muscle.

Cite This Study

Yamakawa et al. (1990) studied this question.

synapsesocial.com/papers/6a73643bc8f0e053d4566345 https://doi.org/10.1085/jgp.95.4.697

View Full Paper

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Mechanical transients of single toad stomach smooth muscle cells. Effects of lowering temperature and extracellular calcium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanical transients of single toad stomach smooth muscle cells. Effects of lowering temperature and extracellular calcium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider