This basic science study demonstrates that smooth muscle cross-bridges are more compliant and have slower state transitions compared to striated muscle.
These mechanical differences in animal models warrant no clinical changes; leaves open whether they inform human smooth muscle therapies.
Tension transients were recorded in a single smooth muscle cell. The transient contains a linear elastic response and a biphasic recovery that appear to originate from the cross-bridges. A comparison of transients in smooth and fast skeletal muscle fibers suggests that the cross-bridge in smooth muscle is more compliant than the cross-bridge in striated muscle and that transitions between several cross-bridge states occur more slowly in smooth muscle than in striated muscle.
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Warshaw et al. (1983) studied this question.
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