Tension transients during the rise of tetanic tension in frog muscle fibres.
Population
Fibres isolated from the tibialis anterior muscle of the frog
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for two-step cross-bridge attachment in skeletal muscle; leaves open translation to cardiac mechanics.
Structured PICO
P
Population
Fibres isolated from the tibialis anterior muscle of the frog
I
Intervention
Length steps complete within 0.2 ms applied at one end of the fibre
O
Outcome
Tension transients and stiffness changes during the rise of tetanic tensionsurrogate
The study demonstrates that stiffness increases earlier than tension during the rise of tetanic force in frog muscle fibers, suggesting a two-step process for cross-bridge attachment.
Cite This Study
Ford et al. (1986) studied this question.