Key result
In tetanized single frog muscle fibres, hypertonic solution reduced steady force by 19% at the isometric tetanus plateau and markedly reduced the tension-to-stiffness ratio by 23%.
Hypertonicity reduces steady force and alters the tension-to-stiffness ratio in tetanized frog skeletal muscle fibers during isometric conditions.
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Hypertonicity may alter isolated muscle mechanics; leaves open relevance to cardiac contractility and should not change practice.
Piazzesi et al. (1994) studied this question. Hypertonic Ringer solution (98 mM sucrose) vs. Normal Ringer solution was evaluated on Tension transient following a step change in sarcomere length. In tetanized single frog muscle fibres, hypertonic solution reduced steady force by 19% at the isometric tetanus plateau and markedly reduced the tension-to-stiffness ratio by 23%.
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