The study provides mechanistic insights into muscular contraction, suggesting a long-lived state between crossbridge attachment and force generation.
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No direct clinical relevance; leaves open validation of long-lived crossbridge states in human myocardium.
Instantaneous stiffness of frog skeletal muscle, an indication of the proportion of attached crossbridges, was determined drug the tetanus rise and after a step length change imposed during the tetanus plateau. During the onset of contraction as well as after a step, the ratio of stiffness to force differed from that determined during the tetanus plateau. The data after a step are predicted by the Huxley-Simmons model of muscular contraction, but the results during the rise suggest that a long-lived state may exist between crossbridge attachment and force generation.
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Cecchi et al. (1982) studied this question.
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