May 1, 1989Journal of Biological ChemistryOpen Access

Slight changes in conditions influence the family of non-B-DNA conformations of the herpes simplex virus type 1 DR2 repeats

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Population

Plasmids carrying eight contiguous copies of DR2 sequences from the segment inversion site of herpes simplex…

Design

Preclinical

Authors

FWFranz WohlrabMax Perutz Labs RWRobert D. WellsUniversity of Bern

Discussion

Member takes

Implication

Physiological non-B-DNA transitions in HSV-1 DR2 may support replication; leaves open functional validation and antiviral targeting.

Structured PICO

Population

Plasmids carrying eight contiguous copies of DR2 sequences from the segment inversion site of herpes simplex virus type 1

Intervention

Changes in environmental conditions (pH 5.0, presence of divalent cations Mg2+ and Ca2+, increasing NaCl concentrations)

Outcome

Supercoil-driven conformational transitions resulting in different extents of relaxationsurrogate

The existence of non-B-DNA conformations and structural transitions of DR2 repeats under physiological conditions implies their involvement in the life cycle of herpes simplex virus type 1.

Cite This Study

Wohlrab et al. (1989) studied this question.

synapsesocial.com/papers/6a84422f25efb1e71e83e93d https://doi.org/10.1016/s0021-9258(18)83170-2

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Slight changes in conditions influence the family of non-B-DNA conformations of the herpes simplex virus type 1 DR2 repeats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Slight changes in conditions influence the family of non-B-DNA conformations of the herpes simplex virus type 1 DR2 repeats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider